Description

tert-Butyl-2-Chloro-2-Trimethylsilylacetate is a specialized organosilicon reagent featuring a protected carboxylic acid group and a reactive chloro substituent. This compound is a critical building block in advanced organic synthesis, enabling the controlled introduction of functionalized acetate units under mild conditions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of α-chloroacetate derivatives used in active pharmaceutical ingredient (API) synthesis.
• Peptide Mimetics: Employed in the synthesis of non-natural amino acids and peptide backbone modifications.
• Agrochemical Synthesis: Building block for creating novel herbicides and fungicides with tailored properties.
• Polymer Chemistry: Monomer or initiator for specialty polymers and silicone-based hybrid materials.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Nucleophilic Substitution: The chloro group is readily displaced by various nucleophiles, facilitating diverse functional group transformations.
• Protecting Group Strategy: The tert-butyl ester acts as a robust protecting group for carboxylic acids during multi-step syntheses.

Basic Information

Product Name	tert-Butyl-2-Chloro-2-Trimethylsilylacetate
CAS No.	66406-43-7
Molecular Formula	C9H19ClO2Si
Molecular Weight	222.78 g/mol
Synonyms	2-Chloro-2-(trimethylsilyl)acetic acid tert-butyl ester; tert-Butyl 2-chloro-2-(trimethylsilyl)acetate; Acetic acid, 2-chloro-2-(trimethylsilyl)-, 1,1-dimethylethyl ester; 2-Chloro-2-trimethylsilylacetic acid tert-butyl ester; (2-Chloro-2-trimethylsilyl-acetic acid) tert-butyl ester; t-Butyl 2-chloro-2-(trimethylsilyl)acetate; TBDMS-CCl2-COOtBu (abbrev.)
EINECS	Contact for details

Quality Control

Our tert-Butyl-2-Chloro-2-Trimethylsilylacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.