Description

2-Nitro-4-Azidophenylsulfenyl Chloride is a specialized aromatic sulfenyl chloride derivative, distinguished by its reactive nitro and azido functional groups. This compound is a critical high-value intermediate for synthesizing photoaffinity labels, cross-linking agents, and other advanced materials in chemical biology and materials science. It is primarily sought by research institutions, pharmaceutical R&D departments, and specialty chemical manufacturers developing novel probes, polymers, and surface modification technologies.

Application

• Photoaffinity Labeling Probes: A key building block for creating covalent photo-crosslinking reagents used to study protein-ligand interactions and biological target identification.
• Polymer & Material Science: Serves as a functional monomer or cross-linker for introducing photoreactive and click-chemistry handles into polymers, hydrogels, and surface coatings.
• Bioconjugation Chemistry: Used to synthesize heterobifunctional linkers for attaching dyes, drugs, or other molecules to proteins, antibodies, or nanoparticles under controlled, light-activated conditions.
• Organic Synthesis Intermediate: Employed in the preparation of more complex sulfenamide, disulfide, or thioether compounds for pharmaceutical and agrochemical research.
• Surface Functionalization: Enables the covalent attachment of specific functional groups to material surfaces (e.g., gold, silicon) for sensor development and advanced material fabrication.

Basic Information

Product Name	2-Nitro-4-Azidophenylsulfenyl Chloride
CAS No.	66365-13-7
Molecular Formula	C6H3ClN4O2S
Molecular Weight	230.63 g/mol
Synonyms	4-Azido-2-nitrobenzenesulfenyl chloride; 1-Azido-4-(chlorosulfenyl)-2-nitrobenzene; 2-Nitro-4-azidobenzenesulfenyl chloride; NSC 402104; 4-Azido-2-nitro-phenylsulfenyl chloride; (4-Azido-2-nitrophenyl)sulfenyl chloride; Benzenesulfenyl chloride, 4-azido-2-nitro-
EINECS	Contact for details

Quality Control

Every batch of 2-Nitro-4-Azidophenylsulfenyl Chloride is produced and analyzed under strict quality protocols to ensure consistency and reliability for sensitive research applications. Our products undergo rigorous quality testing, including HPLC purity analysis and spectroscopic identification, to meet exacting research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and hygroscopic nature, this material should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent decomposition and moisture uptake. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.