Description

8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol is a versatile spirocyclic acetal-protected alcohol, a key chiral building block and intermediate in advanced organic synthesis. Its value lies in its unique sterically hindered structure, which is crucial for introducing specific stereochemistry and functional groups into complex target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries developing novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Building Block: Serves as a precursor for fragrances, flavors, and other high-value specialty chemicals requiring precise molecular architecture.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new catalytic systems for stereoselective reactions.
• Material Science Monomer: Potential use in synthesizing specialized polymers with unique thermal or mechanical properties.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, particularly in reactions involving protected carbonyls and alcohols.

Basic Information

Item	Details
Product Name	8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol
CAS No.	66336-42-3
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol; 8-Hydroxy-8-methyl-1,4-dioxaspiro[4.5]decane; 8-Methyl-8-hydroxy-1,4-dioxaspiro[4.5]decane; Spirocyclic acetal alcohol; 8-Methyl-1,4-dioxaspiro[4,5]decan-8-ol; 1,4-Dioxaspiro[4.5]decan-8-ol, 8-methyl-; (8-Methyl-1,4-dioxaspiro[4.5]decan-8-yl) alcohol
EINECS	Contact for details

Quality Control

Our 8-Methyl-1,4-dioxaspiro[4.5]decan-8-ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profile is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as required)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.