Description

Trimethyl Orthoisobutyrate is a specialized orthoester compound, a key building block in organic synthesis. Its primary value lies in its role as a versatile reagent for the protection of carboxylic acids and the synthesis of complex molecules. This high-purity intermediate is essential for manufacturers in the pharmaceutical and agrochemical sectors, where precise chemical transformations are critical for developing active ingredients and fine chemicals.

Application

• Pharmaceutical Synthesis: A crucial reagent for the protection of carboxylic acid groups during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used as an intermediate in the production of advanced pesticides, herbicides, and plant growth regulators.
• Fine Chemical Production: Serves as a building block for synthesizing complex esters, flavors, and fragrances.
• Polymer Chemistry: Acts as a modifier or cross-linking agent in the development of specialty polymers and resins.
• Research & Development: Employed in academic and industrial R&D labs for methodological studies and novel compound library generation.
• Chemical Derivatization: Utilized for analytical purposes to derivative compounds for improved detection in chromatographic methods.

Basic Information

Product Name	Trimethyl Orthoisobutyrate
CAS No.	66226-66-2
Molecular Formula	C7H16O3
Molecular Weight	148.20 g/mol
Synonyms	Trimethyl 2-Methylpropane-1,1,1-triyl Orthoformate; 2-Methylpropane-1,1,1-triyl Trimethyl Orthoformate; Orthoisobutyric Acid Trimethyl Ester; Trimethyl Ortho-2-methylpropanoate; Isobutyl Orthoformate, Trimethyl Derivative; TMIB; Trimethyl Isobutyl Orthoformate
EINECS	Contact for details

Quality Control

Our Trimethyl Orthoisobutyrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including Gas Chromatography (GC) and NMR, to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.395 - 1.405
Density (20°C)	0.92 - 0.96 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.