Description

(S)-2-Hydroxysuccinic Acid Methyl Ester CAS NO 66212-45-1 is a high-purity chiral building block and intermediate of significant value in asymmetric synthesis. This compound matters because its defined stereochemistry enables the production of enantiomerically pure pharmaceuticals and fine chemicals, ensuring high biological activity and process efficiency. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing advanced active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in cardiovascular and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for metal-catalyzed reactions such as hydrogenation and cross-coupling.
• Agrochemical Synthesis: Serves as a building block for creating chiral active ingredients in herbicides and pesticides with improved efficacy and environmental profile.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Biochemical Research: Utilized as a standard or reagent in enzymatic studies and metabolic pathway analysis.
• Polymer Modification: Acts as a monomer or co-monomer for introducing chiral centers into specialty polymers.

Basic Information

Item	Details
Product Name	(S)-2-Hydroxysuccinic Acid Methyl Ester
CAS No.	66212-45-1
Molecular Formula	C5H8O5
Molecular Weight	148.11 g/mol
Synonyms	(S)-Methyl 2-Hydroxysuccinate; (S)-Methyl Malate; Methyl (S)-(-)-Malate; (S)-Methyl 2-Hydroxybutanedioate; L-Methyl Malate; (2S)-2-Hydroxybutanedioic Acid 1-Methyl Ester; Methyl L-Malate; (S)-(-)-Methyl Malate
EINECS	Contact for details

Quality Control

Our (S)-2-Hydroxysuccinic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with high-grade specifications. Certificates of Analysis (COA) documenting identity, purity, and enantiomeric excess are available upon request, supporting your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.