Description

n-Cbz-1,2,3,6-Tetrahydropyridine is a versatile and high-purity protected amine building block, essential for advanced organic synthesis and pharmaceutical research. Its primary value lies in serving as a key intermediate for constructing complex nitrogen-containing heterocycles, which are core scaffolds in numerous active pharmaceutical ingredients (APIs). This compound is critically needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of piperidine-based drug candidates, including central nervous system (CNS) agents and receptor modulators.
• Medicinal Chemistry Research: Used in parallel and combinatorial synthesis for creating focused libraries to explore structure-activity relationships (SAR).
• Peptidomimetic Synthesis: Serves as a protected amino acid analog for constructing peptide-like molecules with enhanced metabolic stability.
• Agrochemical Development: Intermediate in the production of novel herbicides, fungicides, and insecticides that incorporate the tetrahydropyridine moiety.
• Catalyst Ligand Precursor: Used in the preparation of chiral ligands for asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring high-purity, protected heterocyclic amines.

Basic Information

Product Name	n-Cbz-1,2,3,6-Tetrahydropyridine
CAS No.	66207-23-6
Molecular Formula	C₁₃H₁₅NO₂
Molecular Weight	217.26 g/mol
Synonyms	1,2,3,6-Tetrahydro-1-[(phenylmethoxy)carbonyl]pyridine; 1-N-Cbz-1,2,3,6-Tetrahydropyridine; 1-(Benzyloxycarbonyl)-1,2,3,6-tetrahydropyridine; N-Carbobenzyloxy-1,2,3,6-tetrahydropyridine; N-Cbz-δ³-piperideine; 1-[(Benzyloxy)carbonyl]-1,2,3,6-tetrahydropyridine; Benzyl 1,2,3,6-tetrahydropyridine-1-carboxylate; 1,2,3,6-Tetrahydro-1-pyridinecarboxylic acid phenylmethyl ester
EINECS	Contact for details

Quality Control

Our n-Cbz-1,2,3,6-Tetrahydropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete analytical data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.