Description

Butanedioic Acid, 2-Hydroxy-, 4-(Phenylmethyl) Ester, (2S)- is a high-purity chiral intermediate of significant importance in asymmetric synthesis. This compound, with CAS number 66178-06-1, is valued for its role in constructing complex molecular architectures with precise stereochemistry. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of enantiomerically pure drugs and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic and stoichiometric asymmetric reactions to induce chirality.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.
• Academic & Industrial Research: Serves as a valuable reagent in R&D laboratories for method development and exploring new synthetic pathways.
• Peptide Mimetics & Modifications: Potential use in the synthesis of peptide analogs and modified amino acid derivatives.

Basic Information

Product Name	Butanedioic Acid, 2-Hydroxy-, 4-(Phenylmethyl) Ester, (2S)-
CAS No.	66178-06-1
Molecular Formula	C12H14O5
Molecular Weight	238.24 g/mol
Synonyms	(2S)-2-Hydroxybutanedioic acid 4-benzyl ester; (S)-2-Hydroxysuccinic acid 4-benzyl ester; (S)-Malic acid benzyl ester; Benzyl (S)-malate; L-Malic acid benzyl ester; (S)-(-)-Malic acid benzyl ester; 4-Benzyl (2S)-2-hydroxybutanedioate
EINECS	Contact for details

Quality Control

Our Butanedioic Acid, 2-Hydroxy-, 4-(Phenylmethyl) Ester, (2S)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and specific parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.