Description

2-Oxo-1-[4-(Trifluoromethyl)Benzyl]-1,2-Dihydro-3-Pyridinecarboxylic Acid is a high-value, synthetically versatile organic compound characterized by its pyridinecarboxylic acid core and trifluoromethylbenzyl substituent. This structure makes it a critical advanced pharmaceutical intermediate (API) and a key building block for medicinal chemistry research. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors for the development of novel active ingredients. The compound's properties facilitate its use in creating molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Research: Serves as a core scaffold in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization due to its privileged heterocyclic structure.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of organic electronic materials and functional polymers requiring specific fluorinated aromatic components.

Basic Information

Product Name	2-Oxo-1-[4-(Trifluoromethyl)Benzyl]-1,2-Dihydro-3-Pyridinecarboxylic Acid
CAS No.	66158-46-1
Molecular Formula	C15H10F3NO3
Molecular Weight	309.24 g/mol
Synonyms	1,2-Dihydro-2-oxo-1-[4-(trifluoromethyl)benzyl]-3-pyridinecarboxylic Acid; 1-(4-Trifluoromethylbenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic Acid; 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]-; 2-Oxo-1-(4-trifluoromethylbenzyl)-1,2-dihydropyridine-3-carboxylic Acid; 1-(4-(Trifluoromethyl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic Acid; 2-Oxo-1-(α,α,α-trifluoro-p-tolyl)-1,2-dihydronicotinic Acid; 66158-46-1 (CAS Name)
EINECS	Contact for details

Quality Control

Every batch of 2-Oxo-1-[4-(Trifluoromethyl)Benzyl]-1,2-Dihydro-3-Pyridinecarboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.