Description

Succinimido p-Fluorobenzoate is a high-purity, activated ester derivative of p-fluorobenzoic acid, serving as a critical building block for the site-specific introduction of fluorinated aromatic moieties. This compound matters for its role in advanced bioconjugation and cross-linking strategies, enabling the precise modification of peptides, proteins, and other biomolecules under mild conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical, diagnostic, and life science reagent industries for developing targeted therapeutics, fluorescent probes, and novel chemical biology tools.

Application

• Bioconjugation Reagent: For the selective labeling and modification of antibodies, peptides, and proteins with fluorinated tags.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs containing p-fluorobenzoate esters.
• Cross-linking Agent: Facilitates the creation of stable covalent bonds between biomolecules in assay development and material science.
• Fluorescent Probe Synthesis: A key precursor for constructing advanced imaging agents and diagnostic markers.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide chemistry to incorporate fluorinated aromatic amino acid analogs.
• Polymer Functionalization: Used to introduce reactive succinimidyl ester groups onto polymer backbones for subsequent coupling.
• Chemical Biology Research: A valuable tool for studying protein function, interactions, and localization through targeted chemical modification.

Basic Information

Product Name	Succinimido p-Fluorobenzoate
CAS No.	66134-67-6
Molecular Formula	C11H8FNO4
Molecular Weight	237.18 g/mol
Synonyms	N-Hydroxysuccinimide 4-Fluorobenzoate; 4-Fluorobenzoic Acid N-Hydroxysuccinimide Ester; p-Fluorobenzoic Acid Succinimidyl Ester; NHS-Fluorobenzoate; 4-Fluorobenzoyloxy-2,5-pyrrolidinedione; 1-[(4-Fluorobenzoyl)oxy]-2,5-pyrrolidinedione; N-Succinimidyl 4-Fluorobenzoate; Succinimidyl 4-Fluorobenzoate
EINECS	Contact for details

Quality Control

Our Succinimido p-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.