Description

Trimethylsilyl Diethylphosphonoacetate is a versatile organosilicon reagent and a key Horner-Wadsworth-Emmons (HWE) reagent used in organic synthesis. This compound is highly valued for its role in facilitating carbon-carbon bond formation, specifically in the synthesis of α,β-unsaturated esters and other complex organic molecules. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and high-purity intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing olefin linkages via the Horner-Wadsworth-Emmons reaction.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides where specific alkene structures are required.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials that incorporate phosphonate and silyl ester functionalities.
• Fine Chemical Production: Serves as a key building block for synthesizing flavors, fragrances, and other specialty chemicals requiring precise olefination steps.
• Academic & R&D Laboratories: A staple reagent for methodological development in organic chemistry and for the synthesis of complex natural product analogs.

Basic Information

Product Name	Trimethylsilyl Diethylphosphonoacetate
CAS No.	66130-90-3
Molecular Formula	C9H21O4PSi
Molecular Weight	252.32 g/mol
Synonyms	Diethyl (Trimethylsilyloxycarbonylmethyl)phosphonate; (Trimethylsilyl) Diethylphosphonoacetate; Diethyl (Trimethylsilyl)phosphonoacetate; Diethyl [(Trimethylsilyl)oxy]acetomethylphosphonate; TMS-Diethylphosphonoacetate; (Carboxymethyl)phosphonic Acid Diethyl Ester Trimethylsilyl Ester; Acetic Acid, (Diethoxyphosphinyl)-, Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Diethylphosphonoacetate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.