Description

3-Pyridinecarbonyl Chloride, 5-(Aminocarbonyl)- (9Ci) is a high-purity, multifunctional heterocyclic building block. This compound is valued for its dual reactive sites—the acid chloride and the carboxamide—which enable its use in the synthesis of complex, functionalized pyridine derivatives. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system or possessing kinase inhibitory activity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the pyridine scaffold for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of functional organic molecules for electronic materials, sensors, or advanced polymers.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise functionalization on the pyridine ring.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 5-(Aminocarbonyl)- (9Ci)
CAS No.	66115-80-8
Molecular Formula	C7H5ClN2O2
Molecular Weight	184.58 g/mol
Synonyms	5-Carbamoylnicotinoyl Chloride; 5-Carbamoylpyridine-3-carbonyl Chloride; 3-Pyridinecarboxylic Acid, 5-Carbamoyl-, Chloride; Nicotinoyl Chloride, 5-Carbamoyl-; 5-Aminocarbonylnicotinoyl Chloride; Isonicotinamide, 5-Chlorocarbonyl-; 5-Cyanoaminonicotinoyl Chloride (related)
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarbonyl Chloride, 5-(Aminocarbonyl)- is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.