Description

4-(S-Ethanol)-Sulfido-Cyclophosphamide is a specialized chemical intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of targeted therapeutic agents, particularly within the field of oncology. Pharmaceutical R&D laboratories and fine chemical manufacturers are the primary industrial users who need this high-purity intermediate for producing novel drug candidates and conducting critical metabolic studies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel cyclophosphamide analogs and targeted chemotherapeutic agents.
• Metabolite Research: Used in pharmacological and metabolic studies to understand the biotransformation pathways of alkylating agents.
• Anticancer Drug Development: Employed in R&D for creating prodrugs with potentially improved therapeutic indexes and reduced side-effect profiles.
• Bioconjugation Chemistry: Acts as a functionalized intermediate for attaching cytotoxic payloads to antibodies or other targeting molecules (ADC research).
• Biochemical Tool Compound: Utilized in academic and industrial laboratories to study DNA alkylation mechanisms and cell cycle arrest.
• Process Chemistry: Integrated into scaled-up GMP manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-(S-Ethanol)-Sulfido-Cyclophosphamide
CAS No.	65882-95-3
Molecular Formula	C7H15Cl2N2O2PS
Molecular Weight	293.15 g/mol
Synonyms	4-Hydroxyethylthio Cyclophosphamide; 4-(2-Hydroxyethylthio)cyclophosphamide; NSC 347215; 2-[Bis(2-chloroethyl)amino]-4-(2-hydroxyethylsulfanyl)-1,3,2λ5-oxazaphosphinan-2-one; 4-(β-Hydroxyethylthio)cyclophosphamide; 4-(2-Hydroxyethylmercapto)cyclophosphamide; Cyclophosphamide metabolite analog
EINECS	Contact for details

Quality Control

Every batch of 4-(S-Ethanol)-Sulfido-Cyclophosphamide is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.