Description

(Difluoromethyl)Trimethylsilane CAS NO 65864-64-4 is a versatile organosilicon reagent featuring a reactive difluoromethyl group. This compound is highly valued in synthetic organic chemistry for its ability to introduce the difluoromethyl moiety, a key structural motif in modern pharmaceuticals and agrochemicals. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries seeking to enhance the metabolic stability and bioavailability of their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing the difluoromethyl group, which improves metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluoromethyl group enhances biological activity.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the creation of specialty polymers and advanced materials with unique surface properties.
• Organic Synthesis Reagent: Employed in nucleophilic difluoromethylation reactions to construct complex organic molecules in medicinal chemistry research.
• Ligand and Catalyst Development: Utilized in the preparation of novel fluorinated ligands for catalytic systems.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference compound or a synthetic handle for introducing an NMR-active 19F label.

Basic Information

Product Name	(Difluoromethyl)Trimethylsilane
CAS No.	65864-64-4
Molecular Formula	C4H10F2Si
Molecular Weight	124.21 g/mol
Synonyms	Difluoromethyltrimethylsilane; Trimethyl(difluoromethyl)silane; (Difluoromethyl)trimethylsilicon; TMSCHF2; Silane, difluoromethyltrimethyl-; TMSCF2H; (Difluoromethyl)trimethylsilane (TMSCHF2); 1,1-Difluoro-1-(trimethylsilyl)methane
EINECS	Contact for details

Quality Control

Our (Difluoromethyl)Trimethylsilane is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile and hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture ingress and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.