Description

n-Boc-4-Nitro-L-Phenylalanine Methyl Ester is a protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in the orthogonal protection strategy, where the tert-butoxycarbonyl (Boc) group safeguards the amine functionality, allowing for selective reactions at other sites under a wide range of conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of peptide-based therapeutics, protease inhibitors, and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting enzymatic pathways.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of modified phenylalanine residues.
• Protease Inhibitor Development: Serves as a core structure for designing and optimizing inhibitors for various proteases due to the nitro-phenylalanine moiety.
• Chemical Biology Research: Employed in the creation of activity-based probes and labeled peptides for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new lead compounds.
• Agrochemical Research: Potential intermediate in the development of advanced, targeted crop protection agents.

Basic Information

Item	Details
Product Name	n-Boc-4-Nitro-L-Phenylalanine Methyl Ester
CAS No.	65615-89-6
Molecular Formula	C15H20N2O6
Molecular Weight	324.33 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-nitrophenyl)propanoic acid methyl ester; Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(4-nitrophenyl)propanoate; Boc-4-NO2-Phe-OMe; Boc-L-4-Nitrophenylalanine methyl ester; N-Boc-4-nitro-L-phenylalanine methyl ester; N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine methyl ester; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, methyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-4-Nitro-L-Phenylalanine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥98% by HPLC), and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.