Description

(3R,5R,10'As)-5-(3-Furyl)-4,5,6',6'Aβ,9',10'-Hexahydro-8'α-Methylspiro[Furan-3(2H),7'(8'H)-Naphtho[1,8A-C]Furan]-2,3'(5'H)-Dione CAS NO 65596-26-1 is a complex, high-purity spirocyclic furan derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and synthetic intermediate for the development of novel pharmacologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in complex stereoselective transformations due to its defined (3R,5R,10'As) configuration.
• Natural Product Analog Synthesis: Acts as a core structure for constructing analogs of complex natural products containing spiro or furan motifs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for advanced chemical entities.
• Chemical Biology Probes: Can be functionalized to create molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Details
Product Name	(3R,5R,10'As)-5-(3-Furyl)-4,5,6',6'Aβ,9',10'-Hexahydro-8'α-Methylspiro[Furan-3(2H),7'(8'H)-Naphtho[1,8A-C]Furan]-2,3'(5'H)-Dione
CAS No.	65596-26-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5-(3-Furyl)-4,5,6',6'Aβ,9',10'-hexahydro-8'α-methylspiro[furan-3(2H),7'(8'H)-naphtho[1,8a-c]furan]-2,3'(5'H)-dione, (3R,5R,10'As)-; Spiro[naphtho[1,8a-c]furan-7'(8'H),3'-furan]-2,3'(5'H)-dione derivative; CAS 65596-26-1; (3R,5R,10aS)-5-(3-Furyl)-4,5,6,6a,9,10-hexahydro-8a-methylspiro[furan-3(2H),7'(8'H)-naphtho[1,8a-c]furan]-2,3'(5'H)-dione (alternative stereochemistry notation); Complex spiro furan dione.
EINECS	Contact for details

Quality Control

Our (3R,5R,10'As)-5-(3-Furyl)-4,5,6',6'Aβ,9',10'-Hexahydro-8'α-Methylspiro[Furan-3(2H),7'(8'H)-Naphtho[1,8A-C]Furan]-2,3'(5'H)-Dione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure high chemical and stereochemical purity suitable for research and development applications. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep the container tightly sealed in a dry environment to prevent any potential moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.