Description

L-Proline, 5-(Cyanomethylene)-, Methyl Ester, (E)- (9Ci) is a high-value, non-proteinogenic proline derivative characterized by its unique cyanomethylene side chain. This compound serves as a sophisticated chiral building block and key intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized fine chemicals. Its defined stereochemistry and reactive functional groups make it indispensable for medicinal chemistry and asymmetric synthesis projects.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and peptidomimetic design.
• Peptide Chemistry: Used to introduce constrained proline analogs or specific functional handles into synthetic peptides to modulate their biological activity and stability.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective reactions to create enantiomerically pure compounds.
• Chemical Biology Research: Serves as a probe or building block for studying enzyme mechanisms, protein-ligand interactions, and metabolic pathways.
• Fine Chemical Production: An intermediate in the multi-step synthesis of complex, high-value specialty chemicals for agrochemical and material science applications.
• Academic & Industrial R&D: Utilized in exploratory chemistry for developing new synthetic methodologies and novel molecular entities.

Basic Information

Item	Details
Product Name	L-Proline, 5-(Cyanomethylene)-, Methyl Ester, (E)- (9Ci)
CAS No.	65571-72-4
Molecular Formula	C9H12N2O2
Molecular Weight	180.20 g/mol
Synonyms	(E)-Methyl 2-(cyanomethylene)pyrrolidine-2-carboxylate; (E)-Methyl 5-(cyanomethylene)-L-prolinate; Methyl (2S,5E)-5-(cyanomethylene)-2-pyrrolidinecarboxylate; L-Proline, 5-(cyanomethylene)-, methyl ester, (E)-; (E)-Methyl 2-((cyanomethylene)pyrrolidine-2-carboxylate); (E)-5-(Cyanomethylene)-L-proline methyl ester
EINECS	Contact for details

Quality Control

Our production of L-Proline, 5-(Cyanomethylene)-, Methyl Ester, (E)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment. We support cGMP-compliant manufacturing for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.