Description

Pyridine, 2-(3S)-3-Piperidinyl-, Hydrochloride (1:2) is a high-purity, chiral piperidine-pyridine derivative supplied as a dihydrochloride salt. This compound is a critical chiral building block and intermediate in advanced pharmaceutical synthesis, valued for its defined stereochemistry and salt form which enhances stability and handling. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development and production of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules and APIs.
• Organic Synthesis Building Block: Used in research-scale and process chemistry for constructing nitrogen-containing heterocycles.
• Ligand and Catalyst Precursor: Serves as a starting material for the development of chiral ligands and organocatalysts.
• Chemical Reference Standard: Employed as a high-purity standard in analytical method development and quality control laboratories.
• Agrochemical Research: Investigated as an intermediate in the development of novel crop protection agents.

Basic Information

Item	Details
Product Name	Pyridine, 2-(3S)-3-Piperidinyl-, Hydrochloride (1:2)
CAS No.	65477-76-1
Molecular Formula	C10H16N2 · 2HCl
Molecular Weight	245.17 g/mol (free base: 164.25)
Synonyms	(3S)-2-(3-Piperidinyl)pyridine dihydrochloride; (S)-2-(Piperidin-3-yl)pyridine dihydrochloride; 2-[(3S)-3-Piperidinyl]pyridine hydrochloride (1:2); (S)-2-(3-Piperidyl)pyridine dihydrochloride; 2-(3S-Piperidin-3-yl)pyridine dihydrochloride; (S)-2-Piperidin-3-yl-pyridine dihydrochloride; (S)-2-(3-Piperidino)pyridine dihydrochloride; (S)-2-(3-Piperidinyl)pyridine dihydrochloride
EINECS	Contact for details

Quality Control

Our Pyridine, 2-(3S)-3-Piperidinyl-, Hydrochloride (1:2) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.