Description

1-Bromo-3-(tert-Butyldimethylsiloxy)Benzene is a high-value, protected aromatic intermediate essential for advanced organic synthesis. This compound matters because it provides a versatile and reactive bromine handle while the tert-butyldimethylsilyl (TBDMS) group offers orthogonal protection for the phenolic hydroxyl, enabling precise, multi-step synthetic sequences. Chemical manufacturers and R&D laboratories need it for the production of complex molecules, particularly in the pharmaceutical and agrochemical sectors where it serves as a key building block for active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring selective functionalization of aromatic rings.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the bromine atom facilitates further cross-coupling reactions.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	1-Bromo-3-(tert-Butyldimethylsiloxy)Benzene
CAS No.	65423-56-5
Molecular Formula	C₁₂H₁₉BrOSi
Molecular Weight	287.27 g/mol
Synonyms	3-Bromophenyl tert-Butyldimethylsilyl Ether; 3-Bromo-1-[(tert-butyldimethylsilyl)oxy]benzene; 3-Bromophenol TBDMS Ether; 1-Bromo-3-[(tert-butyldimethylsilyl)oxy]benzene; 3-Bromophenyloxy-tert-butyldimethylsilane; TBDMS 3-Bromophenyl Ether; 3-Bromophenoxy-tert-butyldimethylsilane
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(tert-Butyldimethylsiloxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ISO standards for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.