Description

Glutamic Acid, 1-Methyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block for the controlled introduction of glutamic acid residues, enabling the creation of complex peptides and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and specialty chemical sectors for applications requiring precise molecular construction.

Application

• Pharmaceutical Intermediates: A key synthon in the synthesis of peptide-based drugs, prodrugs, and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected glutamic acid precursor to prevent unwanted side reactions.
• Bioconjugation & Linker Chemistry: Employed in the development of antibody-drug conjugates (ADCs) and other bioconjugates where a specific, modifiable carboxyl group is required.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway research involving glutamate derivatives.
• Fine Chemical Production: Acts as a chiral building block for the manufacture of non-peptidic compounds with specific stereochemical requirements.
• Flavor & Fragrance Precursors: Utilized in the synthesis of complex flavor enhancers and aroma molecules.

Basic Information

Product Name	Glutamic Acid, 1-Methyl Ester
CAS No.	65414-79-1
Molecular Formula	C6H11NO4
Molecular Weight	161.16 g/mol
Synonyms	L-Glutamic acid 1-methyl ester; Methyl L-glutamate; (S)-1-Methoxy-1,5-dioxopentan-2-aminium; 1-Methyl L-glutamate; Methyl glutamate; Glutamic acid methyl ester; H-Glu-OMe; L-Glu-OMe
EINECS	Contact for details

Quality Control

Our Glutamic Acid, 1-Methyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.