Description

4-Fluoro-3-Nitrophenyl Isocyanate is a versatile and highly reactive aromatic isocyanate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the precise introduction of both a reactive isocyanate group and electron-withdrawing nitro and fluoro substituents onto a benzene ring, enabling the creation of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a high-purity intermediate for developing active ingredients, dyes, and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting specific receptors where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the nitro and fluoro groups contribute to biological activity and environmental persistence.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for producing polyurethanes, polyureas, and other specialty polymers with tailored thermal and chemical resistance properties.
• Dye & Pigment Manufacturing: Intermediate for synthesizing complex azo dyes and organic pigments, where the isocyanate group facilitates covalent bonding to substrates or other chromophores.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new heterocyclic compounds, urea derivatives, and carbamate-based molecules.
• Ligand & Chelator Synthesis: Building block for creating sophisticated ligands used in catalysis, metal extraction, and diagnostic imaging agents.

Basic Information

Product Name	4-Fluoro-3-Nitrophenyl Isocyanate
CAS No.	65303-82-4
Molecular Formula	C7H3FN2O3
Molecular Weight	182.11 g/mol
Synonyms	1-Fluoro-2-Nitro-4-Isocyanatobenzene; 3-Nitro-4-Fluorophenyl Isocyanate; 4-Fluoro-3-Nitrobenzenisocyanate; 4-Fluoro-3-Nitro-Phenylisocyanate; 4-Fluoro-3-nitrobenzene isocyanate; (4-Fluoro-3-nitrophenyl)carbimidoic acid; Isocyanic acid, (4-fluoro-3-nitrophenyl) ester
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-Nitrophenyl Isocyanate is manufactured and tested under a strict quality management system. We ensure the product meets high-purity standards suitable for research and industrial synthesis. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, open flames, and incompatible materials such as alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.