Description

3'-(3-(2-Chloroethyl)-3-Nitrosourea)-3'-Deoxythymidine is a specialized nucleoside analog derivative, combining the structural motifs of thymidine and a nitrosourea alkylating agent. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a prodrug or a targeted chemotherapeutic agent. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, medicinal chemistry, and the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel anticancer agents and targeted therapies.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of DNA alkylation and cell cycle inhibition.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new nucleoside-based therapeutics.
• Bioconjugation Studies: Acts as a model compound for developing drug-linker systems in antibody-drug conjugate (ADC) research.
• Biochemical Tool: Utilized in laboratory settings to study enzyme interactions and nucleotide metabolism pathways.

Basic Information

Item	Details
Product Name	3'-(3-(2-Chloroethyl)-3-Nitrosourea)-3'-Deoxythymidine
CAS No.	65174-26-7
Molecular Formula	C12H16ClN5O6
Molecular Weight	361.74 g/mol
Synonyms	3'-C-ethan-1-N-(2-chloroethyl)-N-nitrosourea-3'-deoxythymidine; 3'-Deoxythymidine, 3'-[3-(2-chloroethyl)-3-nitrosourea]-; 3'-CNU-3'-deoxythymidine; 3'-(Chloroethylnitrosocarbamoyl)-3'-deoxythymidine; NSC 409962; 1-(2-Chloroethyl)-3-[(2-deoxy-β-D-erythro-pentofuranosyl)oxy]-1-nitrosourea; 3'-[(2-Chloroethyl)nitrosocarbamoyl]thymidine
EINECS	Contact for details

Quality Control

Our 3'-(3-(2-Chloroethyl)-3-Nitrosourea)-3'-Deoxythymidine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.