Description

Boc-His(Tos)-Oh Dcha CAS NO 65057-34-3 is a protected derivative of the amino acid L-Histidine, specifically designed for use in peptide synthesis. This compound is critical for researchers and manufacturers who require precise control over the reactivity of the histidine side chain during solid-phase or solution-phase peptide assembly. It is an essential building block for the pharmaceutical and biotechnology industries, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the controlled, sequential construction of complex peptide chains.
• Solution-Phase Peptide Synthesis: Used in traditional coupling methods for producing custom peptides and peptide fragments.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for drug delivery systems or diagnostic probes.
• Biochemical Research: Employed in studies of enzyme mechanisms, receptor-ligand interactions, and protein structure-function relationships.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive peptide leads.

Basic Information

Product Name	Boc-His(Tos)-Oh Dcha
CAS No.	65057-34-3
Molecular Formula	C26H40N4O6S
Molecular Weight	536.68 g/mol
Synonyms	N-α-Boc-N-π-tosyl-L-histidine dicyclohexylamine salt; Boc-L-histidine(Tos)-OH·DCHA; Boc-His(Tos)-OH·DCHA; tert-Butyloxycarbonyl-Nim-tosyl-L-histidine dicyclohexylammonium salt; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1-(4-methylphenylsulfonyl)-1H-imidazol-4-yl)propanoic acid dicyclohexylamine salt; BOC-HIS(TOS)-OH DCHA SALT; Boc-His(Tos)-OH DCHA salt; Protected L-Histidine derivative
EINECS	Contact for details

Quality Control

Our Boc-His(Tos)-Oh Dcha is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, NMR, and optical rotation analysis, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all relevant specifications. We adhere to cGMP guidelines for the production of materials intended for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	Contact for details
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.