Description

4-(3-(Trifluoromethyl)Phenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its trifluoromethylphenyl-substituted tetrahydropyridine core. This compound is a critical building block in medicinal chemistry, valued for its role in modulating the pharmacokinetic and pharmacodynamic properties of target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) active agents and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethyl group, which can enhance metabolic stability and membrane permeability.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial scaffold in multi-step syntheses for potential APIs targeting specific receptors or enzymes.
• Biochemical Tool Compound: Employed in vitro and in vivo studies to investigate biological pathways and validate novel therapeutic targets.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and process development projects.

Basic Information

Item	Details
Product Name	4-(3-(Trifluoromethyl)Phenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride
CAS No.	65040-68-8
Molecular Formula	C12H13ClF3N
Molecular Weight	263.69 g/mol
Synonyms	4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine hydrochloride; 1,2,3,6-Tetrahydro-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride; 4-(3-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine HCl; 3-(1,2,3,6-Tetrahydropyridin-4-yl)benzotrifluoride hydrochloride; 4-(m-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride; 65040-68-8 (CAS); 4-(α,α,α-Trifluoro-m-tolyl)-1,2,3,6-tetrahydropyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(3-(Trifluoromethyl)Phenyl)-1,2,3,6-Tetrahydropyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP-compliant practices ensures material suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.