Description

Chlorambucil Ethyl Ester CAS NO 64977-24-8 is a key pharmaceutical intermediate and a derivative of the nitrogen mustard alkylating agent chlorambucil. This compound is of significant importance in medicinal chemistry research and development, particularly for the synthesis of targeted anti-cancer prodrugs and novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in oncology drug discovery and chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of chlorambucil prodrugs and other nitrogen mustard-based chemotherapeutic agents.
• Oncology Research: Used in the development and study of novel alkylating agents designed for targeted cancer therapy with potentially reduced systemic toxicity.
• Medicinal Chemistry: Serves as a versatile precursor for structural modifications aimed at improving drug solubility, bioavailability, and tumor selectivity.
• Bioconjugation Studies: Employed in the creation of antibody-drug conjugates (ADCs) where the ester moiety can be utilized for linker attachment.
• Chemical Reference Standard: Used as a high-purity standard in analytical laboratories for quality control and method development.
• Academic Research: A valuable compound for studying the structure-activity relationships (SAR) of nitrogen mustards and their mechanisms of action.

Basic Information

Product Name	Chlorambucil Ethyl Ester
CAS No.	64977-24-8
Molecular Formula	C16H21Cl2NO2
Molecular Weight	330.25 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]benzenebutanoic acid ethyl ester; Ethyl 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate; Ethyl chlorambucil; Chlorambucil ethyl ester; NSC 75768; 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid ethyl ester; p-[N,N-Bis(2-chloroethyl)amino]phenylbutyric acid ethyl ester
EINECS	Contact for details

Quality Control

Our Chlorambucil Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.