Description

(-)-D-Pyroglutamic Acid Methyl Ester is a high-purity chiral building block and intermediate of significant importance in organic synthesis. Its defined stereochemistry and functional groups make it a valuable precursor for the construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for producing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of various active pharmaceutical ingredients (APIs), including protease inhibitors, nootropic agents, and other neurologically active compounds.
• Peptide Synthesis: Used as a protected glutamic acid derivative or as a building block for introducing the pyroglutamyl moiety into peptide chains.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in stereoselective reactions to create enantiomerically pure products.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where specific stereochemistry is crucial for activity.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials requiring high-purity intermediates.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development.

Basic Information

Product Name	(-)-D-Pyroglutamic Acid Methyl Ester
CAS No.	64700-65-8
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	D-(-)-Pyroglutamic Acid Methyl Ester; (R)-5-Oxo-2-pyrrolidinecarboxylic Acid Methyl Ester; Methyl (R)-(-)-2-Pyrrolidone-5-carboxylate; Methyl (R)-5-Oxopyrrolidine-2-carboxylate; (R)-Methyl 5-Oxopyrrolidine-2-carboxylate; D-Pyroglutamic Acid Methyl Ester; (-)-Methyl 5-Oxoproline
EINECS	Contact for details

Quality Control

Our (-)-D-Pyroglutamic Acid Methyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to meet exacting customer requirements. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.