Description

Cyclobutanecarboxylic Acid, 2-Cyano-, Ethyl Ester, trans- (9Ci) is a high-purity, specialized organic building block featuring a functionalized cyclobutane ring system. This compound matters as a critical chiral synthon for the stereoselective synthesis of complex pharmaceutical intermediates and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing constrained, fused-ring systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced stereospecificity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals where the rigid, substituted cyclobutane core imparts specific physical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functional group transformation reactions.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-Cyano-, Ethyl Ester, trans- (9Ci)
CAS No.	64652-33-1
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	trans-2-Cyanocyclobutanecarboxylic Acid Ethyl Ester; Ethyl trans-2-Cyanocyclobutanecarboxylate; trans-Ethyl 2-Cyanocyclobutanecarboxylate; (1R,2S)-rel-2-Cyanocyclobutanecarboxylic Acid Ethyl Ester; 2-Cyanocyclobutanecarboxylic Acid Ethyl Ester, trans-; Cyclobutanecarboxylic acid, 2-cyano-, ethyl ester, trans-; Ethyl (1R,2S)-2-cyanocyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 2-Cyano-, Ethyl Ester, trans- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.