Description

2-Chloro-5-(Pyrrolidine-1-Sulfonyl)-Pyridine is a high-purity, functionalized pyridine derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and critical building block for medicinal chemistry and agrochemical research, enabling the introduction of both halogen and sulfonamide functionalities. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting kinase inhibition or requiring specific sulfonamide pharmacophores.
• Agrochemical Research: Used in developing novel herbicides, fungicides, or insecticides where the chloropyridine-sulfonamide structure confers specific biological activity.
• Chemical Biology & Proteomics: Employed as a reactive handle or linker in the design of chemical probes, affinity labels, or PROTACs (Proteolysis Targeting Chimeras).
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers with tailored electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring this specific molecular architecture.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and organosulfur chemistry.

Basic Information

Item	Details
Product Name	2-Chloro-5-(Pyrrolidine-1-Sulfonyl)-Pyridine
CAS No.	64614-51-3
Molecular Formula	C9H11ClN2O2S
Molecular Weight	246.71 g/mol
Synonyms	2-Chloro-5-(pyrrolidine-1-sulfonyl)pyridine; 2-Chloro-5-pyrrolidin-1-ylsulfonylpyridine; 5-(Pyrrolidine-1-sulfonyl)-2-chloropyridine; 2-Chloro-5-(1-pyrrolidinylsulfonyl)pyridine; Pyrrolidine, 1-[(6-chloro-3-pyridinyl)sulfonyl]-; 1-[(6-Chloropyridin-3-yl)sulfonyl]pyrrolidine; 64614-51-3 (CAS); 2-Chloro-5-pyrrolidinosulfonylpyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Pyrrolidine-1-Sulfonyl)-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.