Description

(1R,2S,5R)-5-Methyl-2-Isopropylcyclohexyl 5-Oxo-L-Prolinate is a high-purity, stereochemically defined chiral intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. Pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) need this material for its precise stereochemistry and reliable quality in complex, multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and production of proprietary drug candidates.
• Neurological Drug Development: Used in the synthesis of compounds targeting specific receptors within the central nervous system.
• Metabolic Disorder Research: Serves as a precursor in the creation of molecules for diabetes and obesity-related therapeutic research.
• Peptidomimetic Synthesis: Acts as a constrained proline analog for constructing novel peptide-like structures with enhanced stability.
• Asymmetric Catalysis Ligand Precursor: Provides a chiral scaffold for the development of novel catalysts used in enantioselective synthesis.
• Academic & Contract Research: Employed in university and CRO settings for medicinal chemistry programs and process development.

Basic Information

Product Name	(1R,2S,5R)-5-Methyl-2-Isopropylcyclohexyl 5-Oxo-L-Prolinate
CAS No.	64519-44-4
Molecular Formula	C16H27NO3
Molecular Weight	281.39 g/mol
Synonyms	L-Menthyl 5-oxoproline; (-)-Menthyl L-pyroglutamate; (1R,2S,5R)-(-)-Menthyl (S)-5-oxopyrrolidine-2-carboxylate; 5-Oxo-L-proline (-)-menthyl ester; L-Pyroglutamic acid (-)-menthyl ester; (-)-Menthyl L-pyroglutamate; (S)-5-Oxopyrrolidine-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
EINECS	Contact for details

Quality Control

Our (1R,2S,5R)-5-Methyl-2-Isopropylcyclohexyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Production adheres to cGMP principles where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support our clients with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.