Description

5-[p-[Bis(2-Chloroethyl)Amino]Phenyl]Valeric Acid is a specialized nitrogen mustard derivative, a key chemical class known for its alkylating properties. This compound serves as a critical intermediate in the synthesis of targeted pharmaceutical agents, particularly in oncology research and development. It is essential for medicinal chemists and pharmaceutical manufacturers engaged in creating novel chemotherapeutic and targeted drug conjugates, where precise molecular architecture is paramount for efficacy and safety.

Application

• Pharmaceutical Intermediate: Primary use as a building block in the synthesis of nitrogen mustard-based anticancer drugs and prodrugs.
• Antineoplastic Agent Research: Key starting material for the development of novel alkylating chemotherapeutic agents in preclinical and clinical research.
• Targeted Drug Conjugate (ADC) Development: Used in the creation of antibody-drug conjugates (ADCs) and other targeted delivery systems for cancer therapy.
• Bioconjugation Chemistry: Employed in linking cytotoxic payloads to carriers like peptides, antibodies, or polymers for enhanced therapeutic targeting.
• Biochemical Research: Utilized in studies investigating DNA alkylation mechanisms and cellular response to alkylating agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-[p-[Bis(2-Chloroethyl)Amino]Phenyl]Valeric Acid
CAS No.	64508-90-3
Molecular Formula	C15H21Cl2NO2
Molecular Weight	318.24 g/mol
Synonyms	5-[4-[Bis(2-chloroethyl)amino]phenyl]pentanoic acid; 4-[Bis(2-chloroethyl)amino]benzenepentanoic Acid; NSC 342008; Chlorambucil Impurity; Phenylacetic acid, 4-[bis(2-chloroethyl)amino]-, ω-carboxybutyl ester (related); Nitrogen mustard valeric acid derivative
EINECS	Contact for details

Quality Control

Our 5-[p-[Bis(2-Chloroethyl)Amino]Phenyl]Valeric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.