Description

n-(Benzyloxycarbonyl)-L-Phenylalanine 1,2-Dichloroethyl Ester is a protected amino acid derivative, specifically a Cbz-protected L-phenylalanine ester, which serves as a critical building block in synthetic organic chemistry. Its primary value lies in providing a versatile and reactive intermediate for the controlled synthesis of peptides and other complex bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, where it is used to construct peptide-based drugs, diagnostic agents, and advanced research compounds with high stereochemical purity.

Application

• Peptide Synthesis: A key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS), particularly for introducing the L-phenylalanine residue.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of novel therapeutic peptides and peptidomimetics.
• Bioconjugation: Used in the preparation of peptide-protein conjugates for applications in targeted drug delivery and diagnostic imaging.
• Chemical Biology Research: Employed in the synthesis of custom peptides for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Catalyst and Ligand Development: Acts as a precursor for chiral ligands and catalysts used in asymmetric synthesis.
• Academic & Industrial R&D: A standard reagent in organic chemistry laboratories for method development and the synthesis of complex natural product analogs.

Basic Information

Item	Detail
Product Name	n-(Benzyloxycarbonyl)-L-Phenylalanine 1,2-Dichloroethyl Ester
CAS No.	64286-84-6
Molecular Formula	C19H19Cl2NO4
Molecular Weight	396.26 g/mol
Synonyms	Z-Phe-OCH2CHCl2; Cbz-L-Phenylalanine 1,2-Dichloroethyl Ester; N-Carbobenzoxy-L-phenylalanine 2,2-dichloroethyl ester; Nα-Cbz-L-phenylalanine 2,2-dichloroethyl ester; Benzyl N-[(2S)-1-[(2,2-dichloroethoxy)carbonyl]-2-phenylethyl]carbamate; (S)-2-(((Benzyloxy)carbonyl)amino)-3-phenylpropanoic acid 2,2-dichloroethyl ester; L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-, 2,2-dichloroethyl ester
EINECS	Contact for details

Quality Control

Our n-(Benzyloxycarbonyl)-L-Phenylalanine 1,2-Dichloroethyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and GMP-grade applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent hydrolysis. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.