Description

5-Bromo-1-(4-Fluorophenyl)-Phthalide is a specialized halogenated phthalide derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its unique molecular structure, featuring both bromine and fluorine substituents, makes it a valuable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry research for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the halogenated phthalide core can contribute to biological activity.
• Material Science: Serves as a monomer or functional additive in the research of specialty polymers and liquid crystals, leveraging its aromatic and halogenated structure.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other transformations to introduce the bromo-fluorophenylphthalide moiety into more complex architectures.
• Chemical Biology Probe Development: Utilized as a scaffold for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	5-Bromo-1-(4-Fluorophenyl)-Phthalide
CAS No.	64169-66-0
Molecular Formula	C14H8BrFO2
Molecular Weight	307.12 g/mol
Synonyms	5-Bromo-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-one; 1-(4-Fluorophenyl)-5-bromophthalide; 5-Bromo-1-(p-fluorophenyl)phthalide; 2-Benzofuran-1-one, 5-bromo-1-(4-fluorophenyl)-1,3-dihydro-; 5-Bromo-1-(4'-fluorophenyl)phthalide
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(4-Fluorophenyl)-Phthalide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.