Description

1-[2-(Aminocarbonyloxy)-3-Propoxypropyl]-5-Ethyl-5-Phenyl-2,4,6(1H,3H,5H)-Pyrimidinetrione is a specialized barbiturate derivative with a unique propoxypropyl carbamate side chain. This compound is valued for its role as a key pharmaceutical intermediate in the synthesis of central nervous system (CNS) active agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel sedative-hypnotic or anesthetic compounds. The product is supplied with a focus on high purity and batch-to-batch consistency to support critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced barbiturate-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical studies to investigate the structure-activity relationships (SAR) of GABAA receptor modulators.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Medicinal Chemistry: A valuable scaffold for designing and synthesizing new chemical entities with potential sedative, hypnotic, or anticonvulsant properties.
• Process Chemistry Development: Utilized in optimizing synthetic routes and scaling up production for potential drug candidates.

Basic Information

Product Name	1-[2-(Aminocarbonyloxy)-3-Propoxypropyl]-5-Ethyl-5-Phenyl-2,4,6(1H,3H,5H)-Pyrimidinetrione
CAS No.	64038-14-8
Molecular Formula	C19H25N3O6
Molecular Weight	391.42 g/mol
Synonyms	5-Ethyl-5-phenyl-1-[2-(ureidooxy)-3-propoxypropyl]barbituric acid; 1-[2-(Carbamoyloxy)-3-propoxypropyl]-5-ethyl-5-phenylbarbituric acid; NSC 163044; U-26,952; Propallylonal carbamate; 5-Ethyl-1-(2-hydroxy-3-propoxypropyl)-5-phenylbarbituric acid carbamate
EINECS	Contact for details

Quality Control

Our 1-[2-(Aminocarbonyloxy)-3-Propoxypropyl]-5-Ethyl-5-Phenyl-2,4,6(1H,3H,5H)-Pyrimidinetrione is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.