Description

4-((Trimethylsilyl)Ethynyl)Morpholine is a specialized organosilicon building block featuring a terminal alkyne protected by a trimethylsilyl (TMS) group and a morpholine moiety. This compound is valued for its dual functionality, serving as a key intermediate in advanced organic synthesis, particularly in click chemistry and metal-catalyzed cross-coupling reactions. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic entities.
• Agrochemical Synthesis: Used in the research and development of advanced crop protection agents, herbicides, and fungicides, leveraging its reactive alkyne functionality.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent in the development of specialty polymers, dendrimers, and functionalized surfaces with tailored properties.
• Click Chemistry Reagent: The TMS-protected alkyne is a valuable participant in Huisgen cycloaddition (copper-catalyzed azide-alkyne cycloaddition or CuAAC) reactions for bioconjugation and polymer labeling.
• Ligand & Catalyst Development: Employed in the synthesis of novel nitrogen-containing ligands for transition metal catalysis, enhancing reaction selectivity and efficiency.
• Organic Synthesis Building Block: Used in Sonogashira coupling and other palladium-catalyzed reactions to introduce ethynyl-morpholine motifs into complex organic molecules.

Basic Information

Product Name	4-((Trimethylsilyl)Ethynyl)Morpholine
CAS No.	64024-63-1
Molecular Formula	C9H17NOSi
Molecular Weight	183.32 g/mol
Synonyms	4-(2-Trimethylsilylethynyl)morpholine; Morpholine, 4-[(trimethylsilyl)ethynyl]-; 4-(Trimethylsilylethynyl)morpholine; 4-(Trimethylsilylethynyl)morpholine; 4-(2-(Trimethylsilyl)ethynyl)morpholine; N-((Trimethylsilyl)ethynyl)morpholine; TMS-Ethynyl Morpholine
EINECS	Contact for details

Quality Control

Our production of 4-((Trimethylsilyl)Ethynyl)Morpholine adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.