Description

(3S)-3-Hydroxy-1-(2-O,3-o-Isopropylidene-β-D-Ribofuranosyl)Pyrrolidin-2-One is a high-purity, protected nucleoside derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for nucleoside analog synthesis and other sophisticated chemical transformations.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of nucleoside-based antiviral and anticancer agents.
• Antiviral Drug Development: Used in the synthesis of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Biochemical Research: Serves as a protected precursor for the study of RNA metabolism, enzyme mechanisms, and cellular signaling pathways.
• Fine Chemical Synthesis: Employed as a specialized building block for constructing complex, stereochemically pure molecules in custom synthesis projects.
• Prodrug Development: Utilized in the design and synthesis of prodrugs to enhance the bioavailability and targeting of therapeutic nucleosides.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs focused on discovering new bioactive molecules.

Basic Information

Product Name	(3S)-3-Hydroxy-1-(2-O,3-o-Isopropylidene-β-D-Ribofuranosyl)Pyrrolidin-2-One
CAS No.	64018-70-8
Molecular Formula	C12H19NO6
Molecular Weight	273.28 g/mol
Synonyms	1-(2,3-O-Isopropylidene-β-D-ribofuranosyl)-3-hydroxypyrrolidin-2-one; (3S)-3-Hydroxy-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-2-pyrrolidinone; 3-Hydroxy-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-2-pyrrolidinone; Isopropylidene-protected ribofuranosyl pyrrolidinone; Protected nucleoside derivative; 64018-70-8; 1-(2,3-O-Isopropylidene-β-D-ribofuranosyl)-3-hydroxy-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our (3S)-3-Hydroxy-1-(2-O,3-o-Isopropylidene-β-D-Ribofuranosyl)Pyrrolidin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.