Description

(3S)-3β,5α-Dimethyl-5-Isoxazolidinecarboxylic Acid Methyl Ester CAS NO 64018-39-9 is a high-purity chiral isoxazolidine derivative, a key synthetic intermediate valued for its defined stereochemistry and functional group versatility. This compound is critical for ensuring the precise stereochemical outcomes required in advanced pharmaceutical synthesis and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing nitrogen heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where specific stereochemistry influences biological activity.
• Asymmetric Catalysis & Ligand Synthesis: Serves as a precursor for chiral ligands or catalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry programs.
• Peptidomimetics & Bioactive Molecule Design: Its isoxazolidine core is a useful scaffold for designing conformationally constrained peptide analogs and other bioactive compounds.

Basic Information

Item	Detail
Product Name	(3S)-3β,5α-Dimethyl-5-Isoxazolidinecarboxylic Acid Methyl Ester
CAS No.	64018-39-9
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	(3S,5R)-3,5-Dimethyl-5-(methoxycarbonyl)isoxazolidine; Methyl (3S,5R)-3,5-dimethyl-1,2-oxazolidine-5-carboxylate; (3S,5R)-3,5-Dimethylisoxazolidine-5-carboxylic acid methyl ester; (3S,5R)-3,5-Dimethyl-5-methoxycarbonylisoxazolidine; (3S,5R)-DMIC-ME; (3S)-3,5-Dimethyl-5-isoxazolidinecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (3S)-3β,5α-Dimethyl-5-Isoxazolidinecarboxylic Acid Methyl Ester is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and standard identification methods, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting purity, assay, and chiral purity are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.