Description

(2R,6R,7α,8β)-7-[(Z)-1,3-Butadienyl]-2-(4-Pentynyl)-1-Azaspiro[5.5]Undecan-8-Ol is a complex, stereochemically defined organic compound featuring a unique spirocyclic azepane core functionalized with both butadienyl and pentynyl side chains. This compound matters as a sophisticated chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures with precise three-dimensional control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-infective drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid spirocyclic scaffold and multiple points for chemical modification.
• Asymmetric Synthesis: Serves as a precursor or template in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Agrochemical Development: Potential intermediate in the synthesis of novel, high-specificity pesticides and herbicides.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying enzyme function or receptor binding, leveraging its alkyne handle for "click chemistry" conjugation.
• Academic & Institutional Research: Employed in universities and R&D institutes for methodological studies in synthetic organic chemistry and heterocyclic chemistry.

Basic Information

Product Name	(2R,6R,7α,8β)-7-[(Z)-1,3-Butadienyl]-2-(4-Pentynyl)-1-Azaspiro[5.5]Undecan-8-Ol
CAS No.	63983-64-2
Molecular Formula	C20H31NO
Molecular Weight	301.47 g/mol
Synonyms	1-Azaspiro[5.5]undecan-8-ol, 7-(1,3-butadienyl)-2-(4-pentynyl)-, (2R,6R,7α,8β)-; (2R,6R,7α,8β)-7-[(1Z)-1,3-Butadien-1-yl]-2-(4-pentyn-1-yl)-1-azaspiro[5.5]undecan-8-ol; (2R,6R,7α,8β)-7-[(Z)-1,3-Butadienyl]-2-(4-pentynyl)-1-azaspiro[5.5]undecan-8-ol; Spirocyclic azepane derivative; Chiral azaspiro compound
EINECS	Contact for details

Quality Control

Our production of (2R,6R,7α,8β)-7-[(Z)-1,3-Butadienyl]-2-(4-Pentynyl)-1-Azaspiro[5.5]Undecan-8-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. All materials undergo rigorous analytical testing, including chiral HPLC for enantiomeric excess determination, NMR for structural confirmation, and GC/HPLC for purity assessment. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.