Description

2-[(2-Chloroethyl)(2-Fluoroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide is a specialized heterocyclic organophosphorus compound of significant interest in advanced chemical synthesis. This molecule is valued for its unique bifunctional reactive sites, making it a versatile intermediate for constructing complex pharmacologically active structures. It is primarily sought by research institutions and pharmaceutical development companies working on novel therapeutic agents, particularly in oncology and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nitrogen mustard and cyclophosphamide analogs for anticancer drug discovery.
• Chemical Biology Research: Used in the development of molecular probes and affinity labels to study enzyme mechanisms and protein interactions.
• Prodrug Development: Serves as a precursor for designing bioreductive prodrugs activated in hypoxic tumor environments.
• Agrochemical Synthesis: An intermediate for creating new generations of herbicides and plant growth regulators with specific modes of action.
• Polymer Modification: Employed to introduce phosphorous-containing functional groups into polymers, altering their flame-retardant or chelating properties.
• Ligand Synthesis for Catalysis: Used to prepare complex phosphine-amine hybrid ligands for asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	2-[(2-Chloroethyl)(2-Fluoroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide
CAS No.	63867-49-2
Molecular Formula	C7H15ClFN2O2P
Molecular Weight	236.63 g/mol
Synonyms	N,N-Bis(2-haloethyl)-1,3,2-oxazaphospholidine 2-oxide; 2-[(2-Chloroethyl)(2-fluoroethyl)amino]-1,3,2-oxazaphospholidine 2-oxide; 1,3,2-Oxazaphospholidine, 2-[(2-chloroethyl)(2-fluoroethyl)amino]tetrahydro-, 2-oxide; Cyclophosphamide analog intermediate; Bifunctional haloethylamino oxazaphosphorine oxide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 2-[(2-Chloroethyl)(2-Fluoroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, impurity profile, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.