Description

Methyl-6-o-(Tert.-Butyldimethylsilyl)-2,3,4-Tri-o-Acetyl-α-D-Glucopyranoside CAS NO 63734-11-2 is a key protected monosaccharide derivative, specifically a methyl glucoside with acetyl and tert-butyldimethylsilyl (TBDMS) protecting groups. This compound is of critical importance as a versatile chiral building block and advanced intermediate in sophisticated organic synthesis. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of complex carbohydrate-based molecules, nucleosides, and glycoconjugates.

Application

• Advanced Pharmaceutical Intermediates: Serves as a crucial precursor in the multi-step synthesis of novel glycosylated drugs and prodrugs.
• Carbohydrate Chemistry Research: Used as a protected glycosyl donor or acceptor for constructing complex oligosaccharides and glycoconjugates with precise stereochemistry.
• Nucleoside & Nucleotide Synthesis: Acts as a key starting material for the preparation of modified sugar moieties in antiviral or anticancer nucleoside analogs.
• Glycobiology Tool Development: Employed in the synthesis of standardized probes, inhibitors, or substrates for studying enzyme mechanisms and biological recognition.
• Process Chemistry & Scale-up: Provides a reliable, high-purity intermediate for optimizing synthetic routes from laboratory to pilot plant scale.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring specialized carbohydrate intermediates.

Basic Information

Product Name	Methyl-6-o-(Tert.-Butyldimethylsilyl)-2,3,4-Tri-o-Acetyl-α-D-Glucopyranoside
CAS No.	63734-11-2
Molecular Formula	C₂₁H₃₈O₉Si
Molecular Weight	462.61 g/mol
Synonyms	Methyl 6-O-(tert-Butyldimethylsilyl)-2,3,4-tri-O-acetyl-α-D-glucopyranoside; Methyl 2,3,4-Tri-O-acetyl-6-O-[(1,1-dimethylethyl)dimethylsilyl]-α-D-glucopyranoside; α-D-Glucopyranoside, methyl 6-O-(1,1-dimethylethyl)dimethylsilyl-2,3,4-tri-O-acetate; Methyl 6-O-TBDMS-2,3,4-tri-O-acetyl-α-D-glucopyranoside; TBDMS-protected methyl glucoside tetraacetate; 1-O-Methyl-2,3,4-tri-O-acetyl-6-O-tert-butyldimethylsilyl-α-D-glucopyranose
EINECS	Contact for details

Quality Control

Our Methyl-6-o-(Tert.-Butyldimethylsilyl)-2,3,4-Tri-o-Acetyl-α-D-Glucopyranoside is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and process development. All materials are characterized by modern analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.