Description

4,5α-Epoxy-17-Methylmorphinan-3,8β-Diol is a specialized morphinan derivative with a defined stereochemical structure. This compound serves as a critical intermediate in advanced pharmaceutical synthesis, particularly for the development of opioid receptor-targeting therapeutics. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of new analgesic agents and neuropharmacological studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent opioid analgesics and antagonists.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new central nervous system (CNS) active compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical production.
• Biochemical Research: Employed in studies investigating opioid receptor binding and signal transduction pathways.
• Process Development: Utilized in scaling up and optimizing synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4,5α-Epoxy-17-Methylmorphinan-3,8β-Diol
CAS No.	63729-84-0
Molecular Formula	C₁₈H₂₃NO₃
Molecular Weight	301.38 g/mol
Synonyms	8β-Hydroxy-4,5α-epoxy-17-methylmorphinan-3-ol; 3,8β-Dihydroxy-4,5α-epoxy-17-methylmorphinan; 17-Methyl-4,5α-epoxymorphinan-3,8β-diol; 4,5α-Epoxy-3,8β-dihydroxy-17-methylmorphinan; Morphinan-3,8β-diol, 4,5α-epoxy-17-methyl-; 8β-Hydroxy-17-methyl-4,5α-epoxymorphinan-3-ol
EINECS	Contact for details

Quality Control

Our 4,5α-Epoxy-17-Methylmorphinan-3,8β-Diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.