Description

Methyl cis-3-Hydroxycyclobutanecarboxylate is a high-purity, functionalized cyclobutane derivative that serves as a versatile chiral building block in advanced organic synthesis. Its unique strained-ring structure combined with hydroxyl and ester functionalities makes it a valuable intermediate for constructing complex molecular architectures. This compound is particularly sought after by research and development teams in the pharmaceutical and agrochemical sectors for applications in medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and antiviral drug research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging its rigid cyclobutane core.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or cross-linking agent for novel polymers with specific thermal or mechanical properties.
• Flavor and Fragrance Industry: Potential intermediate for the synthesis of complex, stereochemically defined aroma chemicals.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Product Name	Methyl cis-3-Hydroxycyclobutanecarboxylate
CAS No.	63485-50-7
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	Methyl (1R,3S)-3-Hydroxycyclobutanecarboxylate; cis-3-Hydroxycyclobutanecarboxylic Acid Methyl Ester; Methyl 3-Hydroxycyclobutanecarboxylate (cis-); (1R,3S)-3-Hydroxycyclobutanecarboxylic Acid Methyl Ester; Methyl cis-3-Hydroxy-1-cyclobutanecarboxylate; 3-Hydroxycyclobutanecarboxylic acid methyl ester, cis-; Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester, cis-
EINECS	Contact for details

Quality Control

Every batch of Methyl cis-3-Hydroxycyclobutanecarboxylate is produced under strict quality management protocols. We employ advanced analytical techniques, including HPLC, GC, and NMR, to ensure identity, purity, and enantiomeric excess meet the stringent requirements of our clients. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.