Description

4-Methoxybenzyl 2-Bromoacetate is a versatile and reactive chemical intermediate, primarily valued for its role as a key building block in organic synthesis. Its molecular structure, featuring both a bromoacetate ester and a methoxybenzyl protecting group, makes it an essential reagent for the controlled introduction of functional groups. This compound is particularly critical for researchers and manufacturers in the pharmaceutical and fine chemical industries who require high-purity intermediates for the development of active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly where the methoxybenzyl (PMB) group serves as a protective group.
• Peptide Synthesis: Used in the preparation of reagents for peptide coupling and the modification of amino acid side chains.
• Alkylating Agent: Functions as an efficient alkylating agent in organic reactions to introduce the -CH2CO2R moiety into target molecules.
• Protecting Group Chemistry: The 4-methoxybenzyl (PMB) ester moiety can act as a protecting group for carboxylic acids, which can be removed under specific, mild conditions.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and specialty materials requiring specific functionalization.
• Agrochemical Synthesis: Serves as an intermediate in the research and production of certain herbicides and plant growth regulators.

Basic Information

Product Name	4-Methoxybenzyl 2-Bromoacetate
CAS No.	63353-51-5
Molecular Formula	C10H11BrO3
Molecular Weight	259.10 g/mol
Synonyms	p-Methoxybenzyl Bromoacetate; 4-Methoxybenzyl Bromoacetate; (4-Methoxyphenyl)methyl 2-bromoacetate; PMB Bromoacetate; Bromoacetic Acid 4-Methoxybenzyl Ester; 2-Bromoacetic Acid 4-Methoxybenzyl Ester; Bromoacetic Acid p-Methoxybenzyl Ester; α-Bromoacetic Acid 4-Methoxybenzyl Ester
EINECS	Contact for details

Quality Control

Our 4-Methoxybenzyl 2-Bromoacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.