Description

(S)-(-)-Methylsuccinic Acid Dimethyl Ester is a high-purity chiral building block of significant importance in asymmetric synthesis. This optically active diester is a versatile intermediate for the production of pharmaceuticals, agrochemicals, and advanced materials. It is particularly valuable for researchers and manufacturers in fine chemical and pharmaceutical development who require enantiomerically pure compounds to create active ingredients with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where the specific stereoisomer can be critical for biological activity and environmental safety.
• Ligand and Catalyst Preparation: Serves as a precursor for the synthesis of chiral ligands and organocatalysts used in asymmetric catalysis.
• Fine Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating complex molecular architectures.
• Flavor and Fragrance Industry: Potential intermediate for the synthesis of stereodefined aroma chemicals and natural product analogs.
• Polymer Modification: Can be used to introduce chiral centers into polymer backbones for specialty materials with unique optical or mechanical properties.

Basic Information

Product Name	(S)-(-)-Methylsuccinic Acid Dimethyl Ester
CAS No.	63163-08-6
Molecular Formula	C7H12O4
Molecular Weight	160.17 g/mol
Synonyms	(S)-(-)-2-Methylbutanedioic Acid Dimethyl Ester; (S)-Dimethyl 2-Methylsuccinate; (S)-(-)-Dimethyl Methylsuccinate; (S)-1,4-Dimethoxy-1,4-dioxobutan-2-ene; (2S)-2-Methylbutanedioic Acid Dimethyl Ester; Methylsuccinic Acid Dimethyl Ester, (S)-(-)- Form; (S)-Methylsuccinic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our (S)-(-)-Methylsuccinic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch is analyzed to ensure high chemical and optical purity, meeting the stringent requirements for chiral intermediates. Comprehensive Certificates of Analysis (COA) are provided, detailing parameters such as assay, enantiomeric excess (e.e.), and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Specific Rotation	[α]20/D: -20° to -25° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.