Description

Estradiol 3,17-Divalerate is a synthetic, diesterified derivative of the natural hormone estradiol, designed for enhanced stability and controlled release. This compound is a critical pharmaceutical intermediate and active ingredient in advanced hormone replacement therapies and other medicinal formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of long-acting parenteral products and transdermal delivery systems.

Application

• Pharmaceutical Active Ingredient (API): Core component in long-acting injectable hormone replacement therapies (HRT) for menopausal symptom management.
• Drug Delivery Systems: Used in the formulation of transdermal patches, implants, and microsphere-based controlled-release systems.
• Veterinary Pharmaceuticals: Employed in estrus synchronization and fertility treatments in livestock and companion animals.
• Biochemical Research: Serves as a reference standard and a key reagent in endocrinology and steroid metabolism studies.
• Advanced Formulation Development: A candidate for novel drug delivery platforms seeking prolonged hormonal activity with reduced dosing frequency.

Basic Information

Product Name	Estradiol 3,17-Divalerate
CAS No.	63042-28-4
Molecular Formula	C26H36O6
Molecular Weight	444.56 g/mol
Synonyms	Estradiol Divalerate; Estradiol 3,17-Dihexanoate; Oestradiol Divalerate; NSC 17591; 3,17β-Dihydroxyestra-1,3,5(10)-trien-3,17-diyl dihexanoate; E2-DV; Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3,17-dihexanoate
EINECS	Contact for details

Quality Control

Our Estradiol 3,17-Divalerate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, ensuring compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.