Description

2-Acetyl-3-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)-Dl-Alanine is a sophisticated, non-natural amino acid derivative that serves as a critical building block in advanced pharmaceutical research and development. This compound is valued for its unique heterocyclic structure, which is integral to modulating biological activity and creating novel molecular entities. It is primarily sought after by medicinal chemists and research organizations in the pharmaceutical and biotechnology sectors for the synthesis of targeted therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for oncology and neurological targets.
• Medicinal Chemistry Research: Used as a core scaffold or side-chain modifier in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Kinase Inhibitor Synthesis: Integral to the construction of novel kinase inhibitor libraries, leveraging the pyrrolopyridine moiety for targeted binding.
• Peptidomimetic Development: Employed in the design and synthesis of peptidomimetics and constrained peptides to enhance metabolic stability and bioavailability.
• Bioconjugation & Probe Chemistry: Serves as a specialty linker or functional handle for creating bioconjugates, fluorescent probes, or affinity labels for biochemical assays.
• Contract Research & Development (CRO): Supplied to CROs and academic institutions engaged in cutting-edge drug discovery programs.

Basic Information

Product Name	2-Acetyl-3-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)-Dl-Alanine
CAS No.	63024-18-0
Molecular Formula	C₁₄H₁₅N₃O₃
Molecular Weight	273.29 g/mol
Synonyms	DL-2-Acetyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)alanine; 3-(7-Azaindol-3-yl)-2-acetylamino-propionic Acid; 2-Acetylamino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic Acid; 2-Acetamido-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic Acid; 3-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-2-(acetyl-DL-alanine); 63024-18-0; 2-Acetyl-3-(1H-7-azaindol-3-yl)-DL-alanine
EINECS	Contact for details

Quality Control

Our 2-Acetyl-3-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)-Dl-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and comprehensive spectroscopic identification (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, impurities, and all relevant physicochemical parameters to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.