Description

Methyl-2-Deoxy-β-D-Ribofuranoside Diacetate is a key protected ribofuranoside derivative, serving as a vital synthetic intermediate in nucleoside chemistry. Its primary value lies in enabling the controlled synthesis of modified nucleosides and oligonucleotides, where the acetyl groups protect reactive hydroxyls during complex coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antiviral agents, anticancer drugs, and novel oligonucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a protected monomer in the solid-phase synthesis of DNA/RNA fragments and antisense oligonucleotides.
• Glycosylation Reactions: Serves as a glycosyl donor in the synthesis of complex carbohydrates and glycoconjugates.
• Biochemical Research: A key reagent in studying enzyme mechanisms, metabolic pathways, and nucleic acid chemistry.
• Prodrug Development: Utilized in the design and synthesis of prodrugs to enhance the bioavailability of nucleoside therapeutics.
• Labeled Compound Synthesis: Intermediate for preparing isotopically labeled (e.g., 13C, 2H) nucleosides for metabolic tracing and imaging studies.

Basic Information

Product Name	Methyl-2-Deoxy-β-D-Ribofuranoside Diacetate
CAS No.	62853-55-8
Molecular Formula	C₁₀H₁₆O₇
Molecular Weight	248.23 g/mol
Synonyms	1,3-Di-O-acetyl-2-deoxy-5-O-methyl-β-D-ribofuranose; Methyl 2-Deoxy-β-D-ribofuranoside Diacetate; 2-Deoxy-5-O-methyl-β-D-ribofuranose 1,3-diacetate; 1,3-Di-O-acetyl-2-deoxy-5-O-methyl-D-ribofuranose; 2-Deoxy-5-O-methyl-1,3-di-O-acetyl-β-D-ribofuranose; 5-O-Methyl-2-deoxy-β-D-ribofuranoside 1,3-diacetate; β-D-Ribofuranoside, methyl 2-deoxy-, 1,3-diacetate
EINECS	Contact for details

Quality Control

Our Methyl-2-Deoxy-β-D-Ribofuranoside Diacetate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and specific tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent decomposition. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.