Description

19-Nor-10-Ketovitamin D3 is a synthetic vitamin D analog and a key intermediate in the research and development of novel therapeutic agents. This compound is valued for its role in studying bone metabolism, cell differentiation, and immune modulation pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity active pharmaceutical ingredients (APIs) for metabolic and oncological research.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced vitamin D receptor modulators and analogs with potential therapeutic applications.
• Biochemical Research: Used as a reference standard and experimental compound in studies of vitamin D metabolism, receptor binding, and gene expression.
• Metabolic Disorder Studies: Investigated in preclinical research for conditions related to calcium homeostasis, such as osteoporosis and secondary hyperparathyroidism.
• Oncology Research: Employed in cellular studies exploring the effects of vitamin D analogs on cell proliferation, differentiation, and apoptosis in various cancer models.
• Academic & Contract Research: Serves as a high-purity reagent for universities and CROs (Contract Research Organizations) conducting fundamental biological research.
• API Development: Used in the process development and scale-up of new chemical entities (NCEs) targeting vitamin D pathways.

Basic Information

Product Name	19-Nor-10-Ketovitamin D3
CAS No.	62743-72-0
Molecular Formula	C₂₆H₄₀O₂
Molecular Weight	384.60 g/mol
Synonyms	19-Nor-10-Oxovitamin D3; 10-Keto-19-Norvitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-1,3-diol, 19-nor-10-oxo-; 19-Nor-10-oxocalcitriol precursor; Vitamin D3 analog 19-nor-10-keto; 10-Oxo-19-norvitamin D3; 19-Nor-10-ketocholecalciferol
EINECS	Contact for details

Quality Control

Our 19-Nor-10-Ketovitamin D3 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and identification by spectroscopic methods (IR, NMR). A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.