Description

Pyrido[3,4-D]Pyrimidin-4(1H)-One, 5,6,7,8-Tetrahydro-7-(Phenylmethyl)-, Dihydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is valued for its role as a key synthetic precursor in the development of novel therapeutic agents, particularly in oncology and kinase inhibitor research. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of targeted kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes for new drug discovery.
• Biochemical Assay Development: Serves as a reference standard or tool compound in high-throughput screening and enzymatic assays.
• Oncology Research: Investigated for its potential as a core scaffold in compounds targeting specific cancer pathways.
• Academic & Contract Research: Employed in university and CRO settings for exploratory synthetic and pharmacological studies.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Pyrido[3,4-D]Pyrimidin-4(1H)-One, 5,6,7,8-Tetrahydro-7-(Phenylmethyl)-, Dihydrochloride
CAS No.	62458-97-3
Molecular Formula	C₁₆H₁₉N₃O • 2HCl
Molecular Weight	350.27 g/mol (free base: 269.34 g/mol)
Synonyms	7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(1H)-one dihydrochloride; 5,6,7,8-Tetrahydro-7-(phenylmethyl)pyrido[3,4-d]pyrimidin-4(1H)-one dihydrochloride; 7-Benzyl-1,4,5,6,7,8-hexahydropyrido[3,4-d]pyrimidin-4-one dihydrochloride; THPP dihydrochloride; CAS 62458-97-3
EINECS	Contact for details

Quality Control

Our Pyrido[3,4-D]Pyrimidin-4(1H)-One, 5,6,7,8-Tetrahydro-7-(Phenylmethyl)-, Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.