Description

2-O,3-o-Bis(Trimethylsilyl)-5-Deoxy-D-Ribo-Pentonic Acid γ-Lactone is a key protected sugar derivative and a versatile synthetic intermediate in advanced organic chemistry. Its value lies in providing a reactive, silyl-protected lactone framework essential for constructing complex nucleoside analogs and modified carbohydrate structures. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on antiviral drug development, nucleotide chemistry, and the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Carbohydrate Chemistry: Serves as a protected precursor for the preparation of deoxy-sugars and other structurally modified carbohydrate derivatives.
• Antiviral Drug Research: Used in the development of prodrugs and modified nucleosides targeting viral polymerases.
• Fine Chemical Synthesis: Employed as a chiral synthon in asymmetric synthesis for creating complex natural products and specialty chemicals.
• Bioconjugation & Probe Development: Useful for introducing sugar moieties into biomolecules or creating labeled compounds for biochemical studies.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	2-O,3-o-Bis(Trimethylsilyl)-5-Deoxy-D-Ribo-Pentonic Acid γ-Lactone
CAS No.	62338-19-6
Molecular Formula	C14H30O4Si2
Molecular Weight	318.56 g/mol
Synonyms	5-Deoxy-2,3-di-O-(trimethylsilyl)-D-ribono-1,4-lactone; 2,3-Di-O-trimethylsilyl-5-deoxy-D-ribono-1,4-lactone; D-Ribo-Pentonic acid, 5-deoxy-2,3-bis-O-(trimethylsilyl)-, γ-lactone; 5-Deoxy-2,3-di-O-trimethylsilyl-D-ribonolactone; TMS-protected ribonolactone; Silylated deoxyribonolactone; 62338-19-6; Bis(trimethylsilyl) deoxyribonolactone derivative
EINECS	Contact for details

Quality Control

Every batch of 2-O,3-o-Bis(Trimethylsilyl)-5-Deoxy-D-Ribo-Pentonic Acid γ-Lactone is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. For long-term storage, consider storing under an inert gas blanket in a desiccator.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.