Description

Methyl-2-Deoxy-3,5-Di-o-p-Nitrobenzoyl-D-Ribofuranoside is a key protected ribofuranoside derivative, specifically designed as a sophisticated building block for nucleoside and oligonucleotide synthesis. Its value lies in providing a chemically stable and reactive intermediate, enabling precise control over the stereochemistry and functionalization of complex carbohydrate-based molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel antiviral agents, anticancer therapeutics, and advanced nucleic acid analogs.

Application

• Nucleoside Analog Synthesis: A critical precursor for the chemical synthesis of modified nucleosides used in antiviral and anticancer drug development.
• Oligonucleotide Production: Serves as a protected monomer or intermediate in the solid-phase or solution-phase synthesis of oligonucleotides for research and therapeutic applications.
• Carbohydrate Chemistry Research: Used in academic and industrial R&D for studying glycosylation reactions and constructing complex sugar moieties.
• Pharmaceutical Intermediate: Employed in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting viral infections and genetic diseases.
• Pro-drug Development: Utilized to create masked or targeted forms of nucleoside-based therapeutics to improve bioavailability and reduce side effects.
• Diagnostic Probe Synthesis: Acts as a starting material for labeled nucleosides used in diagnostic assays and molecular imaging.

Basic Information

Product Name	Methyl-2-Deoxy-3,5-Di-o-p-Nitrobenzoyl-D-Ribofuranoside
CAS No.	62279-73-6
Molecular Formula	C21H20N2O10
Molecular Weight	460.39 g/mol
Synonyms	Methyl 2-Deoxy-3,5-di-O-(4-nitrobenzoyl)-D-ribofuranoside; 1-O-Methyl-2-deoxy-3,5-di-O-(4-nitrobenzoyl)-D-ribofuranose; 2-Deoxy-3,5-di-O-p-nitrobenzoyl-D-ribofuranoside methyl ester; D-Ribofuranoside, methyl 2-deoxy-3,5-bis-O-(4-nitrobenzoyl)-; Methyl 2-deoxy-3,5-di-O-(p-nitrobenzoyl)-D-ribofuranoside; 3,5-Di-O-p-nitrobenzoyl-2-deoxy-D-ribofuranoside methyl ester
EINECS	Contact for details

Quality Control

Our Methyl-2-Deoxy-3,5-Di-o-p-Nitrobenzoyl-D-Ribofuranoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay, impurity profile, and residual solvents to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and reactivity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.