Description

3-(Trimethylsilyloxy)Crotonic Acid Methyl Ester is a versatile organosilicon-protected enol ester, a key building block in advanced organic synthesis. Its value lies in its dual functionality, serving as a masked enolate equivalent for selective C-C bond formation and as a silyl transfer reagent. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of complex drug molecules, including antibiotics, anti-inflammatory agents, and cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its reactivity for constructing specific bioactive frameworks.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialized silicone-based polymers and coatings.
• Organic Synthesis Reagent: Acts as a versatile Michael acceptor or a silyl enol ether equivalent in stereoselective aldol and alkylation reactions.
• Flavor & Fragrance Industry: Employed in the synthesis of specific ester-based aroma chemicals and flavoring agents.
• Academic & R&D: A valuable tool for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	3-(Trimethylsilyloxy)Crotonic Acid Methyl Ester
CAS No.	62269-44-7
Molecular Formula	C8H16O3Si
Molecular Weight	188.30 g/mol
Synonyms	Methyl 3-(Trimethylsilyloxy)crotonate; Methyl 3-(Trimethylsiloxy)-2-butenoate; 2-Butenoic acid, 3-(trimethylsilyloxy)-, methyl ester; 3-(Trimethylsiloxy)crotonic acid methyl ester; TMSO-Crotonate Methyl Ester; Silyl Enol Ether of Methyl Acetoacetate (protected form); (E)-Methyl 3-(trimethylsilyloxy)but-2-enoate
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilyloxy)Crotonic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reliable and reproducible performance in sensitive synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.